Antiviral CD8⁺ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion

Antiviral CD8⁺ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion

CD8⁺ T cell recognition of virus-infected cells is characteristically restricted by major histocompatibility complex (MHC) class I, although rare examples of MHC class II restriction have been reported in Cd4-deficient mice and a macaque SIV vaccine trial using a recombinant cytomegalovirus vector....

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Main Authors: Ranasinghe, Srinika (Author), Lamothe, Pedro A (Author), Soghoian, Damien Z (Author), Cole, Michael B (Author), Yosef, Nir (Author), Jones, R. Brad (Author), Donaghey, Faith (Author), Nwonu, Chioma (Author), Jani, Priya (Author), Clayton, Gina M (Author), Crawford, Frances (Author), White, Janice (Author), Montoya, Alana (Author), Power, Karen (Author), Allen, Todd M (Author), Streeck, Hendrik (Author), Kaufmann, Daniel E (Author), Picker, Louis J (Author), Kappler, John W (Author), Kazer, Samuel Weisgurt (Contributor), Shalek, Alexander K (Contributor), Walker, Bruce (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-02-09T16:29:34Z.
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