Erythropoietin signaling regulates heme biosynthesis

Heme is required for survival of all cells, and in most eukaryotes, is produced through a series of eight enzymatic reactions. Although heme production is critical for many cellular processes, how it is coupled to cellular differentiation is unknown. Here, using zebrafish, murine, and human models,...

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Main Authors: Chung, Jacky (Author), Wittig, Johannes G (Author), Ghamari, Alireza (Author), Maeda, Manami (Author), Dailey, Tamara A (Author), Bergonia, Hector (Author), Kafina, Martin D (Author), Coughlin, Emma E (Author), Minogue, Catherine E (Author), Hebert, Alexander S (Author), Li, Liangtao (Author), Kaplan, Jerry (Author), Lodish, Harvey F (Contributor), Bauer, Daniel E (Author), Orkin, Stuart H (Author), Cantor, Alan B (Author), Maeda, Takahiro (Author), Phillips, John D (Author), Coon, Joshua J (Author), Pagliarini, David J (Author), Dailey, Harry A (Author), Paw, Barry H (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd, 2018-02-09T16:53:30Z.
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