Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor

Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor

Infants with defects in the interleukin 10 receptor (IL10R) develop very early onset inflammatory bowel disease. Whether IL10R regulates lamina propria macrophage function during infant development in mice and whether macrophage-intrinsic IL10R signaling is required to prevent colitis in infancy is...

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Main Authors: Redhu, Naresh S (Author), Bakthavatchalu, Vasudevan (Contributor), Conaway, Evan A (Author), Shouval, Dror S (Author), Tsou, Amy (Author), Goettel, Jeremy A (Author), Biswas, Amlan (Author), Wang, Chuanwu (Contributor), Field, Michael (Author), Muller, Werner (Author), Bleich, Andre (Author), Li, Ning (Author), Gerber, Georg K (Author), Bry, Lynn (Author), Fox, James G (Contributor), Snapper, Scott B (Author), Horwitz, Bruce H (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor)
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd, 2018-02-09T17:09:09Z.
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