Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

Tissue architecture contributes to pancreatic ductal adenocarcinoma (PDAC) phenotypes. Cancer cells within PDAC form gland-like structures embedded in a collagen-rich meshwork where nutrients and oxygen are scarce. Altered metabolism is needed for tumour cells to survive in this environment, but the...

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Main Authors: Olivares, Orianne (Author), Mayers, Jared R. (Contributor), Gouirand, Victoire (Author), Torrence, Margaret E. (Contributor), Gicquel, Tristan (Author), Borge, Laurence (Author), Lac, Sophie (Author), Roques, Julie (Author), Lavaut, Marie-Noëlle (Author), Berthezène, Patrice (Author), Rubis, Marion (Author), Secq, Veronique (Author), Garcia, Stéphane (Author), Moutardier, Vincent (Author), Lombardo, Dominique (Author), Iovanna, Juan Lucio (Author), Tomasini, Richard (Author), Guillaumond, Fabienne (Author), Vander Heiden, Matthew G. (Contributor), Vasseur, Sophie (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-02-12T15:46:57Z.
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