Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis

Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis

Pyruvate kinase (PYK) is an essential glycolytic enzyme that controls glycolytic flux and is critical for ATP production in all organisms, with tight regulation by multiple metabolites. Yet the allosteric mechanisms governing PYK activity in bacterial pathogens are poorly understood. Here we report...

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Main Authors: Zhong, Wenhe (Author), Cui, Liang (Author), Goh, Boon Chong (Author), Cai, Qixu (Author), Ho, Peiying (Author), Chionh, Yok Hian (Author), Yuan, Meng (Author), Sahili, Abbas El (Author), Fothergill-Gilmore, Linda A. (Author), Walkinshaw, Malcolm D. (Author), Lescar, Julien (Author), Dedon, Peter C (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-02-12T16:00:47Z.
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