Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer

Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer

Advanced-stage epithelial ovarian cancers are amongst the most difficult to treat tumors and have proven to be refractory to most cytotoxic, molecularly targeted, or immunotherapeutic approaches. Here, we report that nanoparticle-drug conjugates (NDCs) of monomethyl auristatin E (MMAE) significantly...

Full description

Bibliographic Details
Main Authors: Lauffer, Sam (Author), Matulonis, Ursula (Author), Pepin, David (Author), Birrer, Michael J. (Author), Qi, Ruogu (Contributor), Wang, Yongheng (Contributor), Bruno, Peter Michael (Contributor), Xiao, Haihua (Contributor), Yu, Yingjie (Contributor), Li, Ting (Contributor), Chen, Qixian (Contributor), Kang, Xiang (Contributor), Song, Haiqin (Contributor), Yang, Xi (Contributor), Huang, Xing (Contributor), Detappe, Alexandre (Contributor), Hemann, Michael (Contributor), Ghoroghchian, Paiman Peter (Contributor), Wei, Wei, S.M. Massachusetts Institute of Technology. Department of Civil and Environmental Engineering (Author)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-02-13T19:08:37Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items