The pleiotropic deubiquitinase Ubp3 confers aneuploidy tolerance
Aneuploidy-or an unbalanced karyotype in which whole chromosomes are gained or lost-causes reduced fitness at both the cellular and organismal levels but is also a hallmark of human cancers. Aneuploidy causes a variety of cellular stresses, including genomic instability, proteotoxic and oxidative st...
| Main Authors: | , , , , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Cold Spring Harbor Laboratory,
2018-03-14T17:47:09Z.
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| Subjects: | |
| Online Access: | Get fulltext |