Concise Total Syntheses of (+)-Haplocidine and (+)-Haplocine via Late-Stage Oxidation of (+)-Fendleridine Derivatives
We report the first total syntheses of (+)-haplocidine and its N1-amide congener (+)-haplocine. Our concise synthesis of these alkaloids required the development of a late-stage and highly selective C-H oxidation of complex aspidosperma alkaloid derivatives. A versatile, amide-directed ortho-acetoxy...
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| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS),
2018-03-23T19:48:31Z.
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| Subjects: | |
| Online Access: | Get fulltext |