Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk

Targeting STUB1-tissue factor axis normalizes hyperthrombotic uremic phenotype without increasing bleeding risk

Chronic kidney disease (CKD/uremia) remains vexing because it increases the risk of atherothrombosis and is also associated with bleeding complications on standard antithrombotic/antiplatelet therapies. Although the associations of indolic uremic solutes and vascular wall proteins [such as tissue fa...

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Main Authors: Shashar, Moshe (Author), Belghasem, Mostafa E. (Author), Matsuura, Shinobu (Author), Walker, Joshua (Author), Richards, Sean (Author), Alousi, Faisal (Author), Rijal, Keshab (Author), Kolachalama, Vijaya B. (Author), Odagi, Minami (Author), Nagasawa, Kazuo (Author), Henderson, Joel M. (Author), Gautam, Amitabh (Author), Rushmore, Richard (Author), Francis, Jean (Author), Kirchhofer, Daniel (Author), Sherr, David H. (Author), Ravid, Katya (Author), Chitalia, Vipul C. (Author), Balcells-Camps, Mercedes (Contributor), Kolandaivelu, Kumaran (Contributor), Edelman, Elazer R (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor), Edelman, Elazer R. (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2018-03-26T13:53:27Z.
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