PKM2 is not required for colon cancer initiated by APC loss

PKM2 is not required for colon cancer initiated by APC loss

Background Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been reported to be essential in other tumor contexts, including a proposed non-metabolic...

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Main Authors: Sinnamon, Mark J (Author), Georgeon, Larissa (Author), Yilmaz, Omer H (Author), Di Vizio, Dolores (Author), Hung, Kenneth E (Author), Vander Heiden, Matthew G (Author), Lau, Allison N. (Contributor), Israelsen, William J. (Author), Sinnamon, Mark J. (Author), Dayton, Talya L. (Author), Hillis, Alissandra L. (Contributor), Hung, Kenneth E. (Author), Israelsen, William James (Contributor), Roper, Jatin (Contributor), Yilmaz, Omer (Contributor), Vander Heiden, Matthew G. (Contributor), Dayton, Talya Lucia (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Dayton, Talya L (Contributor)
Format: Article
Language:English
Published: BioMed Central Ltd, 2018-03-29T19:29:06Z.
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