Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

Increased p25, a proteolytic fragment of the regulatory subunit p35, is known to induce aberrant activity of cyclin-dependent kinase 5 (Cdk5), which is associated with neurodegenerative disorders, including Alzheimer's disease. Previously, we showed that replacing endogenous p35 with the noncle...

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Main Authors: Silva, M. Catarina (Author), Sheridan, Steven D. (Author), Lucente, Diane (Author), Gusella, James F. (Author), Dickerson, Bradford C. (Author), Haggarty, Stephen J. (Author), Tsai, Li-Huei (Contributor), Seo, Jinsoo (Contributor), Kritskiy, Oleg (Contributor), Watson, Lauren Ashley (Contributor), Barker, Scarlett Jazmine (Contributor), Dey, Dilip Chandra (Contributor), Raja, Waseem K (Contributor), Lin, Yuan-Ta (Contributor), Ko, Tak (Contributor), Cho, Sukhee (Contributor), Penney, Jay (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Society for Neuroscience, 2018-04-03T15:05:30Z.
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