A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow

A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow

Within a total residence time of 9 min, the sodium salt of ciprofloxacin was prepared from simple building blocks via a linear sequence of six chemical reactions in five flow reactors. Sequential offline acidifications and filtrations afforded ciprofloxacin and ciprofloxacin hydrochloride. The overa...

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Bibliographic Details
Main Authors: Lin, Hongkun (Contributor), Dai, Chunhui (Contributor), Jamison, Timothy F (Contributor), Jensen, Klavs F (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Jamison, Timothy F. (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2018-04-04T15:40:58Z.
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