Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model

Computational analysis reveals the coupling between bistability and the sign of a feedback loop in a TGF-β1 activation model

Background Bistable behaviors are prevalent in cell signaling and can be modeled by ordinary differential equations (ODEs) with kinetic parameters. A bistable switch has recently been found to regulate the activation of transforming growth factor-β1 (TGF-β1) in the context of liver fibrosis, and an...

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Main Authors: Li, Huipeng (Author), Venkatraman, Lakshmi (Author), Narmada, Balakrishnan C (Author), Tucker-Kellogg, Lisa (Author), Narmada, Balakrishnan Chakrapani (Author), White, Jacob K (Contributor), Yu, Hanry (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: BioMed Central, 2018-04-09T14:15:01Z.
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