Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1

PERK signaling is required for cancer invasion and there is interest in targeting this pathway for therapy. Unfortunately, chemical inhibitors of PERK's kinase activity cause on-target side effects that have precluded their further development. One strategy for resolving this difficulty would b...

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Bibliographic Details
Main Authors: Feng, Yu-Xiong (Author), Reinhardt, Ferenc (Author), Jin, Dexter X. (Contributor), Sokol, Ethan Samuel (Contributor), Miller, Daniel Handel (Contributor), Gupta, Piyush (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-04-12T14:33:14Z.
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