Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1
PERK signaling is required for cancer invasion and there is interest in targeting this pathway for therapy. Unfortunately, chemical inhibitors of PERK's kinase activity cause on-target side effects that have precluded their further development. One strategy for resolving this difficulty would b...
Main Authors: | Feng, Yu-Xiong (Author), Reinhardt, Ferenc (Author), Jin, Dexter X. (Contributor), Sokol, Ethan Samuel (Contributor), Miller, Daniel Handel (Contributor), Gupta, Piyush (Contributor) |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor) |
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group,
2018-04-12T14:33:14Z.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
Cancer-specific PERK signaling drives invasion and metastasis through CREB3L1
by: Yu-Xiong Feng, et al.
Published: (2017-10-01) -
De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling
by: Del Vecchio, Catherine A., et al.
Published: (2014) -
De-differentiation confers multidrug resistance via noncanonical PERK-Nrf2 signaling.
by: Catherine A Del Vecchio, et al.
Published: (2014-09-01) -
SMARCE1 is required for the invasive progression of in situ cancers
by: Feng, Yu-Xiong, et al.
Published: (2018) -
BCL11B Drives Human Mammary Stem Cell Self-Renewal In Vitro by Inhibiting Basal Differentiation
by: Cabrera, Janel R., et al.
Published: (2018)