Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity
Immunostimulatory agents such as agonistic anti-CD137 and interleukin (IL)-2 generate effective anti-tumor immunity but also elicit serious toxicities, hampering their clinical application. Here we show that combination therapy with anti-CD137 and an IL-2-Fc fusion achieves significant initial anti-...
| Main Authors: | , , , |
|---|---|
| Other Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group,
2018-05-02T18:13:15Z.
|
| Subjects: | |
| Online Access: | Get fulltext |