Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

In vitro incubation of nanomaterials with plasma offer insights on biological interactions, but cannot fully explain the in vivo fate of nanomaterials. Here, we use a library of polymer nanoparticles to show how physicochemical characteristics influence blood circulation and early distribution. For...

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Bibliographic Details
Main Authors: Grenier, Philippe (Author), Mahmoudi, Morteza (Author), Appel, Eric A. (Author), Lim, Jong-Min (Author), Karnik, Rohit (Author), Farokhzad, Omid C. (Author), Bertrand, Nicolas (Contributor), Martins Lima, Eliana (Contributor), Dormont, Flavio (Contributor), Langer, Robert S (Contributor)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-05-02T19:33:09Z.
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