Optimized Sequence Library Design for Efficient In Vitro Interaction Mapping

Optimized Sequence Library Design for Efficient In Vitro Interaction Mapping

Sequence libraries that cover all k-mers enable universal, unbiased measurements of binding to both oligonucleotides and peptides. While the number of k-mers grows exponentially in k, space on all experimental platforms is limited. Here, we shrink k-mer library sizes by using joker characters, which...

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Bibliographic Details
Main Authors: Puccinelli, Robert (Author), Kim, Ryan (Author), Fordyce, Polly (Author), Orenstein, Yaron (Contributor), Berger Leighton, Bonnie (Contributor)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Mathematics (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-05-16T13:17:47Z.
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