Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways

Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways

Numerous genes and molecular pathways are implicated in neurodegenerative proteinopathies, but their inter-relationships are poorly understood. We systematically mapped molecular pathways underlying the toxicity of alpha-synuclein (α-syn), a protein central to Parkinson's disease. Genome-wide s...

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Bibliographic Details
Main Authors: Khurana, Vikram (Author), Chung, Chee Yeun (Author), Auluck, Pavan K. (Author), Fanning, Saranna (Author), Tardiff, Daniel F. (Author), Bartels, Theresa (Author), Eichhorn, Stephen W. (Author), Benyamini, Hadar (Author), Lou, Yali (Author), Nutter-Upham, Andy (Author), Baru, Valeriya (Author), Freyzon, Yelena (Author), Costanzo, Michael (Author), San Luis, Bryan-Joseph (Author), Schöndorf, David C. (Author), Barrasa, M. Inmaculada (Author), Ehsani, Sepehr (Author), Sanjana, Neville (Author), Zhong, Quan (Author), Gasser, Thomas (Author), Bartel, David P. (Author), Vidal, Marc (Author), Deleidi, Michela (Author), Boone, Charles (Author), Berger, Bonnie (Author), Lindquist, Susan (Author), Peng, Jian (Contributor), Koeva, Martina I (Contributor), Tuncbag, Nurcan (Contributor), Fraenkel, Ernest (Contributor)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-05-16T14:08:09Z.
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