Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies

Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies

Vaccines remain the most effective tool to prevent infectious diseases. Here, we introduce an in vitro booster vaccination approach that relies on antigen-dependent activation of human memory B cells in culture. This stimulation induces antigen- specific B cell proliferation, differentiation of B ce...

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Main Authors: Sanjuan Nandin, Irene (Author), Fong, Carol (Author), Deantonio, Cecilia (Author), Torreno-Pina, Juan A. (Author), Pecetta, Simone (Author), Maldonado, Paula (Author), Gasparrini, Francesca (Author), Kjaer, Svend (Author), Borley, Daryl W. (Author), Nair, Usha (Author), Coleman, Julia A. (Author), Lingwood, Daniel (Author), Meffre, Eric (Author), Poignard, Pascal (Author), Burton, Dennis R. (Author), Batista, Facundo D. (Author), Ordovas-Montanes, Jose Manuel (Contributor), Kazer, Samuel Weisgurt (Contributor), Shalek, Alexander K (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Rockefeller University Press, 2018-05-16T17:00:01Z.
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