Evidence That Gene Activation and Silencing during Stem Cell Differentiation Requires a Transcriptionally Paused Intermediate State

Evidence That Gene Activation and Silencing during Stem Cell Differentiation Requires a Transcriptionally Paused Intermediate State

A surprising portion of both mammalian and Drosophila genomes are transcriptionally paused, undergoing initiation without elongation. We tested the hypothesis that transcriptional pausing is an obligate transition state between definitive activation and silencing as human embryonic stem cells (hESCs...

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Main Authors: Golob, Jonathan L. (Author), Pabon, Lil M. (Author), Pratt, Gabriel A. (Author), Loring, Jeanne F. (Author), Laurent, Louise C. (Author), Murry, Charles E. (Author), Kumar, Roshan (Contributor), Guenther, Matthew (Contributor), Young, Richard A. (Author)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Young, Richard A (Contributor)
Format: Article
Language:English
Published: Public Library of Science (PLoS), 2018-06-11T17:55:16Z.
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