EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling
Tissue regeneration relies on adult stem cells (SCs) that possess the ability to self-renew and produce differentiating progeny. In an analogous manner, the development of certain carcinomas depends on a small subset of tumor cells, called "tumor-initiating cells" (TICs), with SC-like prop...
Main Authors: | Kröger, Cornelia (Author), Ye, Xin (Author), Guen, Vincent (Contributor), Chavarria, Tony E (Contributor), Weinberg, Robert A (Contributor), Lees, Jacqueline (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor) |
Format: | Article |
Language: | English |
Published: |
National Academy of Sciences (U.S.),
2018-06-15T14:30:05Z.
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Subjects: | |
Online Access: | Get fulltext |
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