EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling

Tissue regeneration relies on adult stem cells (SCs) that possess the ability to self-renew and produce differentiating progeny. In an analogous manner, the development of certain carcinomas depends on a small subset of tumor cells, called "tumor-initiating cells" (TICs), with SC-like prop...

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Bibliographic Details
Main Authors: Kröger, Cornelia (Author), Ye, Xin (Author), Guen, Vincent (Contributor), Chavarria, Tony E (Contributor), Weinberg, Robert A (Contributor), Lees, Jacqueline (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2018-06-15T14:30:05Z.
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Online Access:Get fulltext

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