Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA

Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA

The AlkB protein is a repair enzyme that uses an α-ketoglutarate/Fe(II)-dependent mechanism to repair alkyl DNA adducts. AlkB has been reported to repair highly susceptible substrates, such as 1-methyladenine and 3-methylcytosine, more efficiently in ss-DNA than in ds-DNA. Here, we tested the repair...

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Main Authors: Chen, Fangyi (Author), Tang, Qi (Author), Bian, Ke (Author), Humulock, Zachary T. (Author), Yang, Xuedong (Author), Li, Deyu (Author), Jost, Marco (Contributor), Drennan, Catherine L. (Contributor), Essigmann, John M. (Author)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Essigmann, John M (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2018-06-19T13:15:21Z.
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