Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis

Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis

A hallmark of cancer cells is the metabolic switch from oxidative phosphorylation (OXPHOS) to glycolysis, a phenomenon referred to as the 'Warburg effect', which is also observed in primed human pluripotent stem cells (hPSCs). Here, we report that downregulation of SIRT2 and upregulation o...

Full description

Bibliographic Details
Main Authors: Cha, Young (Author), Han, Min-Joon (Author), Cha, Hyuk-Jin (Author), Burkart, Alison (Author), Jung, Jin Hyuk (Author), Jang, Yongwoo (Author), Kim, Chun-Hyung (Author), Jeong, Ho-Chang (Author), Kim, Byung-Gyu (Author), Kahn, C. Ronald (Author), Kim, Kwang-Soo (Author), Zoldan, Janeta (Contributor), Langer, Robert S (Contributor), Guarente, Leonard Pershing (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-06-19T14:18:01Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items