Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

Checkpoint blockade immunotherapies can be extraordinarily effective, but might benefit only the minority of patients whose tumors are pre-infiltrated by T cells. Here, using lung adenocarcinoma mouse models, including genetic models, we show that autochthonous tumors that lacked T cell infiltration...

Full description

Bibliographic Details
Main Authors: Pfirschke, Christina (Author), Engblom, Camilla (Author), Rickelt, Steffen (Contributor), Cortez-Retamozo, Virna (Author), Garris, Christopher (Author), Pucci, Ferdinando (Author), Yamazaki, Takahiro (Author), Poirier-Colame, Vichnou (Author), Newton, Andita (Author), Redouane, Younes (Author), Lin, Yi-Jang (Author), Wojtkiewicz, Gregory (Author), Iwamoto, Yoshiko (Author), Mino-Kenudson, Mari (Author), Huynh, Tiffany G. (Author), Hynes, Richard O. (Contributor), Freeman, Gordon J. (Author), Kroemer, Guido (Author), Zitvogel, Laurence (Author), Weissleder, Ralph (Author), Pittet, Mikael J. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2018-06-22T15:39:51Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items