Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System

Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System

Aneuploidy, a state of karyotype imbalance, is a hallmark of cancer. Changes in chromosome copy number have been proposed to drive disease by modulating the dosage of cancer driver genes and by promoting cancer genome evolution. Given the potential of cells with abnormal karyotypes to become cancero...

Full description

Bibliographic Details
Main Authors: Richardson, Amelia (Author), Iyer, Divya Ramalingam (Author), Wong, Yao Liang (Author), Rhind, Nicholas (Author), Desai, Arshad (Author), Santaguida, Stefano (Contributor), M'Saad, Ons (Contributor), Zasadil, Lauren M (Contributor), Knouse, Kristin Ann (Contributor), Amon, Angelika B (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2018-06-25T14:11:51Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items