Transnuclear TRP1-Specific CD8 T Cells with High or Low Affinity TCRs Show Equivalent Antitumor Activity

Transnuclear TRP1-Specific CD8 T Cells with High or Low Affinity TCRs Show Equivalent Antitumor Activity

We have generated, via somatic cell nuclear transfer, two independent lines of transnuclear (TN) mice, using as nuclear donors CD8 T cells, sorted by tetramer staining, that recognize the endogenous melanoma antigen TRP1. These two lines of nominally identical specificity differ greatly in their aff...

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Bibliographic Details
Main Authors: Dougan, S. K. (Author), Dougan, M. (Author), Turner, J. A. (Author), Ogata, S. (Author), Cho, H.-I (Author), Jaenisch, R. (Author), Celis, E. (Author), Ploegh, H. L. (Author), Kim, Jun (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research (AACR), 2018-06-26T14:39:36Z.
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