Editing DNA Methylation in the Mammalian Genome

Editing DNA Methylation in the Mammalian Genome

Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene expression networks in many biological processes. However, investigation of the functions of specific methylation events remains challenging. Here, we demonstrate that fusion of Tet1 or Dnmt3a with a catalytically inacti...

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Main Authors: Liu, X. Shawn (Author), Wu, Hao (Author), Ji, Xiong (Author), Stelzer, Yonatan (Author), Czauderna, Szymon (Author), Shu, Jian (Author), Dadon, Daniel Benjamin (Contributor), Jaenisch, Rudolf (Contributor), Wu, Xuebing, Ph. D. Massachusetts Institute of Technology (Author), Young, Richard A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Young, Richard A (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-06-26T14:57:06Z.
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