Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart DiseaseNovelty and Significance

Rationale: Therapies that inhibit CETP (cholesteryl ester transfer protein) have failed to demonstrate a reduction in risk for coronary heart disease (CHD). Human DNA sequence variants that truncate the CETP gene may provide insight into the efficacy of CETP inhibition. Objective: To test whether pr...

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Main Authors: Nomura, Akihiro (Author), Won, Hong-Hee (Author), Khera, Amit V. (Author), Takeuchi, Fumihiko (Author), Ito, Kaoru (Author), McCarthy, Shane (Author), Emdin, Connor A. (Author), Klarin, Derek (Author), Natarajan, Pradeep (Author), Gupta, Namrata (Author), Peloso, Gina M. (Author), Borecki, Ingrid B. (Author), Teslovich, Tanya M. (Author), Asselta, Rosanna (Author), Duga, Stefano (Author), Merlini, Piera A. (Author), Correa, Adolfo (Author), Kessler, Thorsten (Author), Wilson, James G. (Author), Bown, Matthew J. (Author), Hall, Alistair S. (Author), Braund, Peter S. (Author), Carey, David J. (Author), Kirchner, H. Lester (Author), Leader, Joseph B. (Author), Lavage, Daniel R. (Author), Manus, J. Neil (Author), Hartze, Dustin N. (Author), Samani, Nilesh J. (Author), Schunkert, Heribert (Author), Marrugat, Jaume (Author), Elosua, Roberto (Author), McPherson, Ruth (Author), Farrall, Martin (Author), Watkins, Hugh (Author), Juang, Jyh-Ming J. (Author), Hsiung, Chao A. (Author), Lin, Shih-Yi (Author), Wang, Jun-Sing (Author), Tada, Hayato (Author), Kawashiri, Masa-aki (Author), Inazu, Akihiro (Author), Yamagishi, Masakazu (Author), Katsuya, Tomohiro (Author), Nakashima, Eitaro (Author), Nakatochi, Masahiro (Author), Yamamoto, Ken (Author), Yokota, Mitsuhiro (Author), Momozawa, Yukihide (Author), Rotter, Jerome I. (Author), Rader, Daniel J. (Author), Danesh, John (Author), Ardissino, Diego (Author), Gabriel, Stacey (Author), Willer, Cristen J. (Author), Abecasis, Goncalo R. (Author), Saleheen, Danish (Author), Kubo, Michiaki (Author), Kato, Norihiro (Author), Ida Chen, Yii-Der (Author), Dewey, Frederick E. (Author), Kathiresan, Sekar (Author), Zekavat, Seyedeh M. (Contributor), Murray, Michael F (Contributor), Lander, Eric Steven (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Ovid Technologies (Wolters Kluwer Health), 2018-06-28T17:47:06Z.
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