RNA targeting with CRISPR-Cas13

RNA targeting with CRISPR-Cas13

RNA has important and diverse roles in biology, but molecular tools to manipulate and measure it are limited. For example, RNA interference1-3 can efficiently knockdown RNAs, but it is prone to off-target effects4, and visualizing RNAs typically relies on the introduction of exogenous tags5. Here we...

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Main Authors: Essletzbichler, Patrick (Author), Belanto, Joseph J. (Author), Verdine, Vanessa (Author), Kellner, Max J. (Author), Voytas, Daniel F. (Author), Gootenberg, Jonathan S (Contributor), Han, Shuo (Contributor), Joung, Julia (Contributor), Cox, David Benjamin Turitz (Contributor), Regev, Aviv (Contributor), Lander, Eric Steven (Contributor), Zhang, Feng (Contributor), Abudayyeh, Omar O. (Author), Ting, Alice Y. (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Abudayyeh, Omar Osama (Contributor), Ting, Alice Y (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-06-28T18:10:20Z.
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