Purine synthesis promotes maintenance of brain tumor initiating cells in glioma
Brain tumor initiating cells (BTICs), also known as cancer stem cells, hijack high-affinity glucose uptake active normally in neurons to maintain energy demands. Here we link metabolic dysregulation in human BTICs to a nexus between MYC and de novo purine synthesis, mediating glucose-sustained anabo...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
---|---|
Other Authors: | , |
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group,
2018-07-02T19:16:37Z.
|
Subjects: | |
Online Access: | Get fulltext |