Purine synthesis promotes maintenance of brain tumor initiating cells in glioma

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma

Brain tumor initiating cells (BTICs), also known as cancer stem cells, hijack high-affinity glucose uptake active normally in neurons to maintain energy demands. Here we link metabolic dysregulation in human BTICs to a nexus between MYC and de novo purine synthesis, mediating glucose-sustained anabo...

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Main Authors: Wang, Xiuxing (Author), Yang, Kailin (Author), Xie, Qi (Author), Wu, Qiulian (Author), Mack, Stephen C (Author), Kim, Leo J Y (Author), Prager, Briana C (Author), Flavahan, William A (Author), Liu, Xiaojing (Author), Singer, Meromit (Author), Hubert, Christopher G (Author), Miller, Tyler E (Author), Zhou, Wenchao (Author), Huang, Zhi (Author), Fang, Xiaoguang (Author), Suvà, Mario L (Author), Hwang, Tae Hyun (Author), Locasale, Jason W (Author), Bao, Shideng (Author), Rich, Jeremy N (Author), Regev, Aviv (Contributor), Shi, Yu, Ph. D. Massachusetts Institute of Technology (Author)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-07-02T19:16:37Z.
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