Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay

Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay

Although studies have identified hundreds of loci associated with human traits and diseases, pinpointing causal alleles remains difficult, particularly for non-coding variants. To address this challenge, we adapted the massively parallel reporter assay (MPRA) to identify variants that directly modul...

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Bibliographic Details
Main Authors: Park, Daniel S. (Author), Liu, Brandon (Author), Winnicki, Sarah (Author), Reilly, Steven K. (Author), Andersen, Kristian G. (Author), Tewhey, Ryan (Contributor), Kotliar, Dylan A. (Contributor), Andersen, Kristian (Contributor), Mikkelsen, Tarjei (Contributor), Lander, Eric Steven (Contributor), Schaffner, Stephen F (Contributor), Sabeti, Pardis (Contributor)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Mathematics (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-07-03T12:29:03Z.
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