A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells

A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells

Reversing the dysfunctional T cell state that arises in cancer and chronic viral infections is the focus of therapeutic interventions; however, current therapies are effective in only some patients and some tumor types. To gain a deeper molecular understanding of the dysfunctional T cell state, we a...

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Main Authors: Singer, Meromit (Author), Cong, Le (Author), Kowalczyk, Monika S. (Author), Zhang, Huiyuan (Author), Nyman, Jackson (Author), Sakuishi, Kaori (Author), Kurtulus, Sema (Author), Gennert, David (Author), Xia, Junrong (Author), Kwon, John Y.H (Author), Nevin, James (Author), Herbst, Rebecca H. (Author), Yanai, Itai (Author), Rozenblatt-Rosen, Orit (Author), Kuchroo, Vijay K. (Author), Anderson, Ana C. (Author), Marjanovic, Nemanja (Contributor), Regev, Aviv (Contributor), Wang, Chao (Author)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Ludwig Center for Molecular Oncology (Massachusetts Institute of Technology) (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-07-03T17:25:17Z.
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