Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase

Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase

A complex interplay of environmental factors impacts the metabolism of human cells, but neither traditional culture media nor mouse plasma mimic the metabolite composition of human plasma. Here, we developed a culture medium with polar metabolite concentrations comparable to those of human plasma (h...

Full description

Bibliographic Details
Main Authors: Cantor, Jason R. (Author), Abu-Remaileh, Monther (Author), Kanarek, Naama (Author), Freinkman, Elizaveta (Author), Gao, Xin (Author), Louissaint, Abner (Author), Lewis, Caroline A. (Author), Sabatini, David (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-07-03T18:03:17Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items