NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent gene essentiality. Here, using loss-of-function screening based on RNA interference, we show that environmental oxygen levels are a major driver of differential essentiality between in vitro model systems and...

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Bibliographic Details
Main Authors: Alvarez, Samantha W. (Author), Sviderskiy, Vladislav O. (Author), Terzi, Erdem M. (Author), Papagiannakopoulos, Thales (Author), Moreira, Andre L. (Author), Adams, Sylvia (Author), Birsoy, Kıvanç (Author), Sabatini, David (Contributor), Possemato, Richard (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-07-03T18:14:37Z.
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