A CRISPR screen identifies a pathway required for paraquat-induced cell death

A CRISPR screen identifies a pathway required for paraquat-induced cell death

Paraquat, a herbicide linked to Parkinson's disease, generates reactive oxygen species (ROS), which causes cell death. Because the source of paraquat-induced ROS production remains unknown, we conducted a CRISPR-based positive-selection screen to identify metabolic genes essential for paraquat-...

Full description

Bibliographic Details
Main Authors: Reczek, Colleen R (Author), Birsoy, Kıvanç (Author), Kong, Hyewon (Author), Martínez-Reyes, Inmaculada (Author), Gao, Peng (Author), Chandel, Navdeep S (Author), Wang, Tim (Contributor), Sabatini, David (Contributor)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-07-03T19:03:49Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items