Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

Mitochondria house metabolic pathways that impact most aspects of cellular physiology. While metabolite profiling by mass spectrometry is widely applied at the whole-cell level, it is not routinely possible to measure the concentrations of small molecules in mammalian organelles. We describe a metho...

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Bibliographic Details
Main Authors: Freinkman, Elizaveta (Author), Birsoy, Kıvanç (Author), Chen, Walter W. (Contributor), Wang, Tim (Contributor), Sabatini, David (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-07-05T13:50:12Z.
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