Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

Chromosome missegregation into a micronucleus can cause complex and localized genomic rearrangements known as chromothripsis, but the underlying mechanisms remain unresolved. Here we developed an inducible Y centromere-selective inactivation strategy by exploiting a CENP-A/histone H3 chimaera to dir...

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Main Authors: Ly, Peter (Author), Kim, Dong H. (Author), Shoshani, Ofer (Author), Skaletsky, Helen (Author), Fachinetti, Daniele (Author), Cleveland, Don W. (Author), Teitz, Levi Shmuel (Contributor), Page, David C (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Springer Nature, 2018-07-05T18:11:05Z.
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