Landscape of X chromosome inactivation across human tissues

Landscape of X chromosome inactivation across human tissues

X chromosome inactivation (XCI) silences transcription from one of the two X chromosomes in female mammalian cells to balance expression dosage between XX females and XY males. XCI is, however, incomplete in humans: up to one-third of X-chromosomal genes are expressed from both the active and inacti...

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Main Authors: Tukiainen, Taru (Author), Villani, Alexandra-Chloé (Author), Rivas, Manuel A. (Author), Marshall, Jamie L. (Author), Satija, Rahul (Author), Aguirre, Matt (Author), Gauthier, Laura (Author), Fleharty, Mark (Author), Kirby, Andrew (Author), Cummings, Beryl B. (Author), Castel, Stephane E. (Author), Karczewski, Konrad J. (Author), Aguet, François (Author), Byrnes, Andrea (Author), Ardlie, Kristin G. (Author), Gelfand, Ellen T. (Author), Getz, Gad (Author), Hadley, Kane (Author), Handsaker, Robert E. (Author), Huang, Katherine H. (Author), Kashin, Seva (Author), Lek, Monkol (Author), Li, Xiao (Author), MacArthur, Daniel G. (Author), Yen, Angela (Contributor), Regev, Aviv (Contributor)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: Springer Nature, 2018-07-05T19:28:22Z.
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