AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma

A causative understanding of genetic factors that regulate glioblastoma pathogenesis is of central importance. Here we developed an adeno-associated virus-mediated, autochthonous genetic CRISPR screen in glioblastoma. Stereotaxic delivery of a virus library targeting genes commonly mutated in human...

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Main Authors: Chow, Ryan D (Author), Guzman, Christopher D (Author), Wang, Guangchuan (Author), Schmidt, Florian (Author), Youngblood, Mark W (Author), Ye, Lupeng (Author), Errami, Youssef (Author), Dong, Matthew B (Author), Martinez, Michael A (Author), Zhang, Sensen (Author), Renauer, Paul (Author), Bilguvar, Kaya (Author), Gunel, Murat (Author), Zhang, Feng (Contributor), Platt, Randall J (Author), Chen, Sidi (Author), Sharp, Phillip A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sharp, Phillip A (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-07-10T14:57:54Z.
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