miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding messenger RNA, leading to increased cell motility and invasiveness. miR-9-mediated E-...

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Main Authors: Prabhala, Harsha (Author), Mestdagh, Pieter (Author), Muth, Daniel (Author), Teruya-Feldstein, Julie (Author), Westermann, Frank (Author), Speleman, Frank (Author), Vandesompele, Jo (Author), Ma, Li-Jun (Contributor), Young, Jennifer J (Contributor), Pan, Elizabeth (Contributor), Reinhardt, Ferenc (Contributor), Onder, Tamer T (Contributor), Valastyan, Scott John (Contributor), Weinberg, Robert A (Contributor)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor)
Format: Article
Language:English
Published: Springer Nature, 2018-07-13T15:58:12Z.
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