Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer

Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer

PI3K inhibition in combination with other agents has not been studied in the context of PIK3CA wild-type, KRAS mutant cancer. In a screen of phospho-kinases, PI3K inhibition of KRAS mutant colorectal cancer cells activated the MAPK pathway. Combination PI3K/MEK inhibition with NVP-BKM120 and PD-0325...

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Main Authors: Roper, Jatin (Author), Sinnamon, Mark J. (Author), Coffee, Erin M. (Author), Belmont, Peter (Author), Keung, Lily (Author), Georgeon-Richard, Larissa (Author), Wang, Wei Vivian (Author), Faber, Anthony C. (Author), Yun, Jihye (Author), Bronson, Roderick T. (Author), Martin, Eric S. (Author), Tsichlis, Philip N. (Author), Hung, Kenneth E. (Author), Yilmaz, Omer (Contributor)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-07-23T19:03:07Z.
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