APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL

APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL

Oncogenic driver mutations are those that provide a proliferative or survival advantage to neoplastic cells, resulting in clonal selection. Although most cancer-causing mutations have been detected in the protein-coding regions of the cancer genome; driver mutations have recently also been discovere...

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Main Authors: Li, Z (Author), Abraham, B J (Author), Berezovskaya, A (Author), Farah, N (Author), Liu, Y (Author), Leon, T (Author), Fielding, A (Author), Tan, S H (Author), Sanda, T (Author), Weintraub, A S (Author), Li, B (Author), Shen, S (Author), Zhang, J (Author), Mansour, M R (Author), Look, A T (Author), Young, Richard A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Young, Richard A (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-07-23T19:12:15Z.
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