Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition
Introduction - Targeted cancer therapeutics have demonstrated more limited clinical efficacy than anticipated, due to both intrinsic and acquired drug resistance. Underlying mechanisms have been largely attributed to genetic changes, but a substantial proportion of resistance observations remain une...
Main Authors: | , , , , |
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Other Authors: | , , , |
Format: | Article |
Language: | English |
Published: |
Springer US,
2018-07-31T15:51:49Z.
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Subjects: | |
Online Access: | Get fulltext |