Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the increased T2D prevalence in Mexico. Here, through genetic fine-mapping, we define a set of tightly linked variants like...

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Main Authors: Rusu, Victor (Author), Hoch, Eitan (Author), Mercader, Josep M. (Author), Tenen, Danielle E. (Author), Gymrek, Melissa (Author), Hartigan, Christina R. (Author), DeRan, Michael (Author), von Grotthuss, Marcin (Author), Fontanillas, Pierre (Author), Spooner, Alexandra (Author), Guzman, Gaelen (Author), Deik, Amy A. (Author), Pierce, Kerry A. (Author), Dennis, Courtney (Author), Clish, Clary B. (Author), Carr, Steven A. (Author), Wagner, Bridget K. (Author), Schenone, Monica (Author), Ng, Maggie C.Y (Author), Chen, Brian H. (Author), Centeno-Cruz, Federico (Author), Zerrweck, Carlos (Author), Orozco, Lorena (Author), Schreiber, Stuart L. (Author), Florez, Jose C. (Author), Jacobs, Suzanne B.R (Author), Shriner, Daniel (Author), Li, Jiang (Author), Chen, Wei-Min (Author), Guo, Xiuqing (Author), Liu, Jiankang (Author), Bielinski, Suzette J. (Author), Yanek, Lisa R. (Author), Nalls, Michael A. (Author), Comeau, Mary E. (Author), Rasmussen-Torvik, Laura J. (Author), Jensen, Richard A. (Author), Evans, Daniel S. (Author), Sun, Yan V. (Author), An, Ping (Author), Patel, Sanjay R. (Author), Lu, Yingchang (Author), Long, Jirong (Author), Armstrong, Loren L. (Author), Wagenknecht, Lynne (Author), Yang, Lingyao (Author), Snively, Beverly M. (Author), Palmer, Nicholette D. (Author), Mudgal, Poorva (Author), Langefeld, Carl D. (Author), Keene, Keith L. (Author), Freedman, Barry I. (Author), Mychaleckyj, Josyf C. (Author), Nayak, Uma (Author), Raffel, Leslie J. (Author), Goodarzi, Mark O. (Author), Chen, Y-D Ida (Author), Taylor, Herman A. (Author), Correa, Adolfo (Author), Sims, Mario (Author), Couper, David (Author), Pankow, James S. (Author), Boerwinkle, Eric (Author), Adeyemo, Adebowale (Author), Doumatey, Ayo (Author), Chen, Guanjie (Author), Mathias, Rasika A. (Author), Vaidya, Dhananjay (Author), Singleton, Andrew B. (Author), Zonderman, Alan B. (Author), Igo, Robert P. (Author), Sedor, John R. (Author), Kabagambe, Edmond K. (Author), Siscovick, David S. (Author), McKnight, Barbara (Author), Rice, Kenneth (Author), Liu, Yongmei (Author), Hsueh, Wen-Chi (Author), Zhao, Wei (Author), Bielak, Lawrence F. (Author), Kraja, Aldi (Author), Province, Michael A. (Author), Bottinger, Erwin P. (Author), Gottesman, Omri (Author), Cai, Qiuyin (Author), Zheng, Wei (Author), Blot, William J. (Author), Lowe, William L. (Author), Pacheco, Jennifer A. (Author), Crawford, Dana C. (Author), Grundberg, Elin (Author), Rich, Stephen S. (Author), Hayes, M. Geoffrey (Author), Shu, Xiao-Ou (Author), Loos, Ruth J.F (Author), Borecki, Ingrid B. (Author), Peyser, Patricia A. (Author), Cummings, Steven R. (Author), Psaty, Bruce M. (Author), Fornage, Myriam (Author), Iyengar, Sudha K. (Author), Evans, Michele K. (Author), Becker, Diane M. (Author), Kao, W.H. Linda (Author), Wilson, James G. (Author), Rotter, Jerome I. (Author), Sale, Michèle M. (Author), Liu, Simin (Author), Rotimi, Charles N. (Author), Bowden, Donald W. (Author), Huerta-Chagoya, Alicia (Author), García-Ortiz, Humberto (Author), Moreno-Macías, Hortensia (Author), Manning, Alisa (Author), Caulkins, Lizz (Author), Burtt, Noël P. (Author), Flannick, Jason (Author), Patterson, Nick (Author), Aguilar-Salinas, Carlos A. (Author), Tusié-Luna, Teresa (Author), Altshuler, David (Author), Martínez-Hernández, Angélica (Author), Barajas-Olmos, Francisco Martin (Author), Contreras-Cubas, Cecilia (Author), Mendoza-Caamal, Elvia (Author), Revilla-Monsalve, Cristina (Author), Islas-Andrade, Sergio (Author), Córdova, Emilio (Author), Soberón, Xavier (Author), González-Villalpando, Clicerio (Author), González-Villalpando, María Elena (Author), Haiman, Christopher A. (Author), Wilkens, Lynne (Author), Le Marchand, Loic (Author), Monroe, Kristine (Author), Kolonel, Laurence (Author), Arellano-Campos, Olimpia (Author), Ordóñez-Sánchez, Maria L. (Author), Rodríguez-Torres, Maribel (Author), Segura-Kato, Yayoi (Author), Rodríguez-Guillén, Rosario (Author), Cruz-Bautista, Ivette (Author), Muñoz-Hernandez, Linda Liliana (Author), Sáenz, Tamara (Author), Gómez, Donají (Author), Alvirde, Ulices (Author), Almeda-Valdés, Paloma (Author), Cortes, Maria L. (Author), Lander, Eric Steven (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Altshuler, David M (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2018-08-01T17:24:05Z.
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