S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models

S-Nitrosylation of PINK1 Attenuates PINK1/Parkin-Dependent Mitophagy in hiPSC-Based Parkinson's Disease Models

Mutations in PARK6 (PINK1) and PARK2 (Parkin) are linked to rare familial cases of Parkinson's disease (PD). Mutations in these genes result in pathological dysregulation of mitophagy, contributing to neurodegeneration. Here, we report that environmental factors causing a specific posttranslati...

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Main Authors: Oh, Chang-Ki (Author), Sultan, Abdullah (Author), Platzer, Joseph (Author), Dolatabadi, Nima (Author), Soldner, Frank (Author), McClatchy, Daniel B. (Author), Diedrich, Jolene K. (Author), Ambasudhan, Rajesh (Author), Nakamura, Tomohiro (Author), Jaenisch, Rudolf (Contributor), Lipton, Stuart A. (Author), Yates, John R., III (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-08-24T14:52:37Z.
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