Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma

Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma

High-risk neuroblastomas show a paucity of recurrent somatic mutations at diagnosis. As a result, the molecular basis for this aggressive phenotype remains elusive. Recent progress in regulatory network analysis helped us elucidate disease-driving mechanisms downstream of genomic alterations, includ...

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Main Authors: Rajbhandari, Presha (Author), Lopez, Gonzalo (Author), Capdevila, Claudia (Author), Salvatori, Beatrice (Author), Yu, Jiyang (Author), Rodriguez-Barrueco, Ruth (Author), Martinez, Daniel (Author), Yarmarkovich, Mark (Author), Weichert-Leahey, Nina (Author), Alvarez, Mariano J. (Author), Iyer, Archana (Author), Harenza, Jo Lynne (Author), Oldridge, Derek (Author), De Preter, Katleen (Author), Koster, Jan (Author), Asgharzadeh, Shahab (Author), Seeger, Robert C. (Author), Wei, Jun S. (Author), Khan, Javed (Author), Vandesompele, Jo (Author), Mestdagh, Pieter (Author), Versteeg, Rogier (Author), Look, A. Thomas (Author), Iavarone, Antonio (Author), Lasorella, Anna (Author), Silva, Jose M. (Author), Maris, John M. (Author), Califano, Andrea (Author), Abraham, Brian Joseph (Contributor), Young, Richard A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Young, Richard A (Contributor)
Format: Article
Language:English
Published: American Association for Cancer Research, 2018-08-24T15:03:01Z.
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