A Blueprint for a Synthetic Genetic Feedback Controller to Reprogram Cell Fate

A Blueprint for a Synthetic Genetic Feedback Controller to Reprogram Cell Fate

To artificially reprogram cell fate, experimentalists manipulate the gene regulatory networks (GRNs) that maintain a cell's phenotype. In practice, reprogramming is often performed by constant overexpression of specific transcription factors (TFs). This process can be unreliable and inefficient...

Full description

Bibliographic Details
Main Authors: Del Vecchio, Domitilla (Contributor), Abdallah, Hussein M. (Contributor), Qian, Yili (Contributor), Collins, James J. (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor), Massachusetts Institute of Technology. Synthetic Biology Center (Contributor)
Format: Article
Language:English
Published: Elsevier, 2018-08-28T15:05:06Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items