Diacylglycerol kinase synthesized by commensal Lactobacillus reuteri diminishes protein kinase C phosphorylation and histamine-mediated signaling in the mammalian intestinal epithelium

Diacylglycerol kinase synthesized by commensal Lactobacillus reuteri diminishes protein kinase C phosphorylation and histamine-mediated signaling in the mammalian intestinal epithelium

Lactobacillus reuteri 6475 (Lr) of thehuman microbiome synthesizes histamine and can suppress inflammation via type 2 histamine receptor (H2R) activation in the mammalian intestine. Gut microbes such as Lr promote H2R signaling and may suppress H1R proinflammatory signaling pathways in parallel by u...

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Main Authors: Ganesh, B P (Author), Ayyaswamy, S (Author), Fultz, R (Author), Major, A (Author), Haag, A (Author), Venable, S (Author), Hall, Alexandra E. (Contributor), Nelson, Jordan William (Contributor), Esparza, Marcos A. (Contributor), Lugo, Michael T (Contributor), Whary, Mark T (Contributor), Fox, James G (Contributor), Versalovic, James (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Mathematics (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor), Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor), Massachusetts Institute of Technology. Institute for Data, Systems, and Society (Contributor), MIT Energy Initiative (Contributor)
Format: Article
Language:English
Published: Springer Nature, 2018-09-05T14:32:58Z.
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