Automated fluorescence intensity and gradient analysis enables detection of rare fluorescent mutant cells deep within the tissue of RaDR mice

Automated fluorescence intensity and gradient analysis enables detection of rare fluorescent mutant cells deep within the tissue of RaDR mice

Homologous recombination (HR) events are key drivers of cancer-promoting mutations, and the ability to visualize these events in situ provides important information regarding mutant cell type, location, and clonal expansion. We have previously created the Rosa26 Direct Repeat (RaDR) mouse model wher...

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Bibliographic Details
Main Authors: Rajapakse, Jagath (Author), Wadduwage, Dushan Nawoda (Contributor), Kay, Jennifer Elizabeth (Contributor), Singh, Vijay Raj (Contributor), Kiraly, Orsolya (Contributor), Sukup Jackson, Michelle Rae (Contributor), Engelward, Bevin P (Contributor), So, Peter T. C. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2018-09-06T19:19:33Z.
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